PLoS ONE 14(5):Įditor: Kandasamy Ulaganathan, Osmania University, INDIA It provides an innovative strategy for easy, reliable, and low cost maintenance of materials containing living fungal mycelium.Ĭitation: Chang J, Chan PL, Xie Y, Ma KL, Cheung MK, Kwan HS (2019) Modified recipe to inhibit fruiting body formation for living fungal biomaterial manufacture. This is the first report of using a GSK-3 inhibitor to suppress fruiting body formation in living fungal mycelium-based materials. We suggest the inclusion of GSK-3 inhibitors in the cultivation recipes for inhibiting fruiting body formation and regulating mycelium growth. Sensitive windows to these inhibitors throughout the fungal life cycle were also identified. The concentrations of glycogen synthase kinase-3 (GSK-3) inhibitors, such as lithium chloride or CHIR99021 trihydrochloride, were found to directly correlate with the development of fruiting bodies in the mushroom forming fungi such as Coprinopsis cinerea and Pleurotus djamor. The objective of this study was to provide a biochemical solution to regulate the fruiting body formation, which may replace heat killing of mycelium in practice. Suppression of fruiting body formation is also a useful tool for maintaining the stability of a mycelium-based material with ease and lower cost. Living fungal mycelium with abolished ability to form fruiting bodies is a self-healing substance, which is particularly valuable for further engineering and development as materials sensing environmental changes and secreting signals.
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